Aim: The aim of the study was to evaluate the efficacy of intravenous iron sucrose versus intravenous iron sucrose and erythropoietin in moderate and severe anemia of pregnancy.

Methods: A total of 50 women with hemoglobin of less than 8 g/dl inthe second or third trimester of pregnancy were enrolled to receive either 1000 mg of intravenous iron sucrose as 5 doses of 200 mg on alternate days (Group I) or to 500 mg of parenteral iron as above with 3 doses of subcutaneous 6000 units each of erythropoietin (Group II).

Results: There was a mean rise of 1.4 g with intravenous iron sucrose there was a mean increaseof 2.8 g/dl with intravenous iron sucrose and erythropoietin therapy. There was significantly high rise in serum iron, serum ferritin, and transferrin saturation. There was no anaphylaxis in any group with iron sucrose and erythropoietin therapy as compared to iron sucrose alone.

Conclusion: Addition of erythropoietin to intravenous iron sucrose gives superior results inimproving hematological parameters in moderate and severe anemia during pregnancy and can obviate the need for blood transfusion.

Keywords: Anemia, Pregnancy, Erythropoietin, Intravenous iron sucrose

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