Objectives: Preeclampsia often complicates pregnancy resulting in adverse impact on maternal and fetal health. Early detection helps in intervention and avoiding adverse outcome of pregnancy. Detection of cell free fetal DNA (cffDNA) in maternal plasma opens the possibility of non-invasive probe into health of fetus.

Methods: Total 50 pregnant women had been recruited from the Antenatal OPD with and without preeclampsia. The women with preeclampsia were considered as case and without preeclampsia were considered as control. cffDNA had been utilized for prenatal diagnosis of adverse pregnancy outcomes.

Result: Among 50 participants, 27 were in preeclampsia group and 23 were in control group. Cell free feta DNA was 55.34 ± 7.232 X 1010 genomic equivalents in preeclampsia group and 11.076 ± 2.345 X 1010 genomic equivalents in control group which is fivefold higher in study group.

Conclusion: Elevated amount of cffDNA in maternal plasma is associated with preeclampsia.

Key words: Cell free fetal DNA, Maternal plasma, Preeclampsia, Pregnancy outcome

Click Here For Reading Continue

For Download  :