Background: Prolonged use of magnesium seizure prophylaxis in resource-constrained regions might delay a mother’s return to normality and thus preclude such recommended practices as kangaroo care. Recently shorter duration of postpartum magnesium sulphate is suggested to compare the use of magnesium sulfate for 12 hours versus 24 hours postpartum on the process of care for women with severe pre-eclampsia and eclampsia.

Methods: Patients with eclampsia who will be admitted during the study period will be randomly assigned to either the study group (12 h MgSO4) or the control group (24 h MgSO4). Women in the study group will be given a loading dose of 4 g of intra-venous MgSO4 (20%), followed by a maintenance dose of 5g MgSO4 (50%) 4 hourly deep intramuscularly in alternate buttocks for 12 hours after the last fit or delivery (whichever will be later).

Result: Total 120 cases of severe pre-eclampsia and eclampsia among them 60 cases for 24 hours MgSO4 therapy (GROUP-A) and 60 cases for 12 hours MgSO4 therapy (GROUP-B) who had fulfilled the eligibility criteria. Distribution of postpartum convulsion of Group-A was 3 vs Group-B was 4 and P value is 0.69691 which is statistically non significance. 

Conclusion: In has been found that 12 hours MgSO4 have almost same efficacy compare to 24 hours MgSO4 therapy. Besides 12 hours MgSO4 therapy has less MgSO4 toxicity like oliguria, respiratory depression, diminish knee jerk as compared to 24 hours MgSO4 therapy.

Keywords: Pregnancy Induced Hypertension (PIH), Eclampsia, Preeclampsia

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