Background - The primary aim of treatment in preeclampsia is to prevent eclamptic seizures, and resultant morbidity and mortality. Magnesium Sulfate has proved to be the optimal drug for seizure prophylaxis.

 Methods: A randomized controlled trial for MgSO4 prophylaxis was conducted between July 2015 to June 2016. Randomization = Sequence generation - Computer generated random numbers. Allocation concealment mechanism - opaque sealed envelopes. Informed consent obtained, subjects were randomly assigned to any of the group.  Intervention Group A – received MgSO4 for 8 hrs. Control Group B – received MgSO4 for 24 hrs.

Results: Out of 45 women in the intervention group A, magnesium sulphate was continued in only 1 woman beyond 8 hours (2.2) [p < 0.001]. The time that doctors spent monitoring the women was significantly less in the group A than in the control group B [p <0.001]. Time spent by the nurses in giving MgSO4 injections and care thereafter was significantly less in the group A (P<0.001). Pain felt by the women due to MgSO4 injection was found to be significantly less in the group A (P<0.001), and women in the intervention group were better able to look after themselves. In group A significant reduction was observed in duration of postpartum Foley’s catheter and time to early ambulation.

Conclusion: The abbreviated regime of is a suitable alternative to the traditional regime and is associated with less exposure to the drug, both in terms of duration and total dose but with similar clinical outcomes.

Key Words:  severe pre-eclampsia, MgSO4 prophylaxis, eclampsia, abbreviated regime

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