Background: The term endometriosis (EMs) is characterized by the growth of endometrial gland and stroma outside the uterine cavity and occur frequently in reproductive age group of women of childbearing age. EMs affecting 6-10% fertile women and may causes abdominal pain and decreased fertility and its recurrence rate is slightly higher than its incidence rate. EMs can migrate to distant tissues including the peritoneum, ovarian and intestinal wall.

Methods: The present study which have been performed included 20 female patients with EMs who were admitted to the Department of Gynecology and Obstetrics of the Jawaharlal Nehru Medical College of Medicine, Kalyani-741235, West Bengal between January 2019 till January 2020.Their normal and abnormal endometrium were collected. As a control, normal endometrial tissues were collected from 20+-2 female subjects with other Gynaecological condition other than EMs within reproductive age group who had undergone complete or partial hysterectomy.

Results: Expression of PAI-1 and miR-30c in EMs tissues: RT-qPCRwas performed to evaluate the expression of PAI-1 and miR-30c in Ems tissues. PAI-1 expression was significantly increased in ectopic and cutopic endometrium compared with normal tissues (P<0.05; Fig). PAI- 1 expression did not significantly differ between ectopic and eutopic endometrium. By contrast, the expression of miRNA-30c was significantly decreased in ectopic and eutopic endometrium compared with normal tissues (P<0.05), however, no difference in miR-30c expression was observed between eutopic and ectopic endometrium.

Conclusions: The present study demonstrated that, in conclusion, that downregulation of miR-30c may be involved in the occurrence and progression of Ems. PAI-l is negatively regulated by miRNA-30c appears to be important in Endometriosis associated process.

Keywords: Endometriosis, Plasminogen activator, Pathophysiology

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